Detection of pancreatic islet tissue following islet allotransplantation in man.

Qualitative and quantitative standards have been recently proposed for islet isolation asaeument in humans and large animals ( 1). The ultimate test of viability is functional activity after transplantation into a diabetic recipient. Morphologic identification of insulin-containing transplanted islets could provide important correlative data and eventually confmn the functional results. Recently. several centers reported prolonged insulin independence after human islet allotransplantation (25). The present report describes the first identification of islet tissue in a liver biopsy after intrahepatic islet allotransplanta-